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Conversations in the health and wellness space are increasingly centered on longevity right now. A new study confirms that Aged Garlic Extract delivers powerful health benefits, with previous research linking it to better energy metabolism, cardiovascular health, and improved muscle strength.
Researchers have identified S-1-propenyl-L-cysteine (S1PC), a naturally occurring compound in aged garlic extract, as a potential supporter of healthy aging. The compound appears to trigger cellular activity in adipose tissue that boosts production of eNAMPT, a protein that plays an important role in regulating NAD+.
The team examined the impact of S1PC through a combination of laboratory, animal, and human studies. Their research included cell culture experiments, tests in aged mice, and a randomized placebo-controlled trial with 40 healthy participants aged 20 to 49. They focused on whether the compound could enhance NAD+ metabolism, which is increasingly recognized as an important factor in aging and long-term health.
Rather than traveling straight to skeletal muscle, eNAMPT appears to exert its effects through the brain. The protein targets the hypothalamus, a key center for regulating metabolism and aging, where it helps replenish NAD+. This brain-driven response enhanced nerve signaling to muscles, leading to better muscle function in aged mice.
The mice in the study that were treated with S1PC for 8 months showed greater muscle strength, stronger grip, and lower frailty than untreated mice. Because muscle size did not increase, the improvements appear to stem from better muscle function and quality. The mice also had higher levels of proteins involved in energy production, suggesting improved metabolic health.
Although it remains unclear whether the muscle benefits seen in mice apply to humans, the study found that adults over 40 with a healthy body weight who took S1PC had higher levels of eNAMPT than those given a placebo. This suggests that the signaling pathway identified in mice may also be active in humans. By uncovering how S1PC may support muscle function, this study offers new insights into potential strategies for combating age-related physical decline.
To view the original scientific study click below:
Garlic-derived metabolite activates LKB1, promotes adipose eNAMPT secretion, and improves age-related muscle function via hypothalamic signaling
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