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New research highlights that Vitamin B3, specifically nicotinamide, may reduce skin cancer risk by up to 54% in individuals with a history of the disease. Dermatologists and skin cancer surgeons frequently recommend nicotinamide to patients, as it helps shield cells from damage associated with UV radiation.
A 2015 clinical trial with 386 participants showed that nicotinamide led to fewer new skin cancer cases in those who took it compared to those who did not. Now, a new large-scale study of about 34,000 veterans has validated that nicotinamide may substantially reduce the risk of developing skin cancer, particularly squamous cell carcinomas. Nicotinamide is also called niacinamide.
The most significant reduction in skin cancer risk was observed in individuals who started taking nicotinamide after their initial skin cancer diagnosis. Across all participants, the supplement reduced skin cancer risk by approximately 14%. When nicotinamide was started after a first skin cancer, the reduced risk rose to 54%. This reduction was noted in non-melanoma skin cancers, including the most common type, basal cell carcinoma, with the greatest decrease seen in cutaneous squamous cell carcinoma.
Squamous cell skin cancers are highly treatable and often removed when caught early, but they can metastasize to other parts of the body. Nicotinamide was less effective at preventing skin cancer in study participants who started taking the Vitamin B3 supplement after being diagnosed with multiple skin cancers.
This research supports the routine use of nicotinamide as a secondary prevention measure for all skin cancer patients, with evidence suggesting that earlier initiation enhances its protective effect. Individuals at elevated risk for skin cancer, particularly those exhibiting precancerous skin changes, may benefit from taking nicotinamide. It is readily available over the counter and is associated with minimal side effects. These findings may encourage earlier, preventive use of nicotinamide in clinical practice.
To view the original scientific study click below:
Nicotinamide for Skin Cancer Chemoprevention
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