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Now researchers have found a way not just to stop, but, reverse the aging process. The key is something called a telomere. We all have them. They are the tips or caps of your chromosomes. They are long and stable in young adults, but, as we age they become shorter, damaged and frayed. When they stop working we start aging and experience things like hearing and memory loss.
In a recent study published in the peer reviewed journal Nature scientists took mice that were prematurely aged to the equivalent of 80-year-old humans, added an enzyme and essentially turned their telomeres back on. After the treatment they were the physiological equivalent of young adults. You can see the before and after pictures in the videos above. Brain function improved, their fertility was restored it was a remarkable reversal of the aging process. In the top video the untreated mouse shows bad skin, gray hair and it is balding. The mouse with it’s telomeres switched back on has a dark coat color, the hair is restored and the coat has a nice healthy sheen to it. Even more dramatic is the change in brain size. Before treatment the aged mice had 75% of a normal size brain like a patient with severe Alzheimers. After the telomeres were reactivated the brain returned to normal size. As for humans while it is just one factor scientists say the longer the telomeres the better the chances for a more graceful aging.
The formal study Telomere dysfunction induces metabolic and mitochondrial compromise was published in Nature.
Additional information published by Harvard can be found in the following articles.
Scientists Find Root Molecular Cause of Declining Health in the Old
While scientists are not yet able to accomplish the same results in humans we believe we have developed a nutraceutical to help prolong youth and possibly extend life until age reversal therapy for humans becomes available.
A recent study in mice reveals that gut microbes can contribute to cognitive decline in old age, suggesting that age-related memory problems may be actively driven by changes in the gut microbiome and the bacteria residing there.
Muscle retains molecular memories when it was strong and when it was weak. These memories accumulate and influence future periods of inactivity. Whether from illness, injury, hospital stays, or falls, muscle wasting occurs and can become a problem that grows more common with age.
While PFAS or “forever chemicals” exert widespread harmful effects, a new study points to PFNA and PFOSA as drivers of accelerated biological aging in men during middle age, an effect notably absent in women. It is estimated that drinking water contaminated with PFAS could have exposed over 200 million Americans. The slow breakdown in the human body means these chemicals build up insidiously, potentially for decades, before any harm becomes evident.