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Researchers in Australia believe they have identified the master regulator of aging. Their study has uncovered the genetic mechanisms that control how individuals mature and age. Previously, the changes in gene activity from birth through adulthood to old age were largely unknown. This groundbreaking discovery could pave the way for enhancing the quality of life as people grow older.
They studied humans and mice in various age groups over a period of time which gave them the opportunity to investigate the gene activity associated with development and aging. Each of our cells are switched on or off by a master controller gene which makes sure that each cell carries out its unique function.
The master regulator, which is called Activator Protein (AP-1) was discovered to gradually activate adult genes, while reducing the process in the development of early-life genes
The study revealed that this cellular process was consistent across a person’s life stages as they mature. It continued into adulthood, presumably because AP-1 can be activated by various stress and inflammatory mechanisms and also by a blood protein that increases as we age. This then suppresses the genes most active when we are young, potentially driving many of the predictable changes associated with aging.
Addressing age-related diseases like Alzheimer's, metabolic liver disorders, and stroke requires a deep understanding of the aging process. By identifying AP-1 as a key regulator influencing aging across various cell types, researchers are now positioned to test drugs that diminish its activity, potentially enhancing life quality. The objective is to halt the progression or onset of aging-related diseases by targeting the core mechanisms of aging, thus promoting healthier aging.
To view the original scientific study click below:
The activity of early-life gene regulatory elements is hijacked in aging through pervasive AP-1-linked chromatin opening
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